Bpsbioscience/Sirtinol/27652-1/5 mg

来自 : 发布时间：2024-12-01

MW: 394.5 Da CAS Registry #: 410536-97-9 Formula: C₂₆H₂₂N₂O₂ Target: SIRT1, SIRT2 Background:Unlike TSA, Sirtinol does not inhibit class I and class II HDACs, indicating that it is a selective sirtuin inhibitor. The downregulation of SIRT1/2 expression plays an important role in the regulation of breast cancer apoptosis; thus, SIRT1/2 may be a novel molecular target for cancer therapy. Description:Cell-permeable, selective sirtuin inhibitor that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro. Synonym(s): 2-[[(Z)-(2-oxonaphthalen-1-ylidene)methyl]amino]-N-(1-phenylethyl)benzamide Purity:

≥98% by HPLC

Solubility: DMSO 23 mg/ml, Water <1 mg/ml, Ethanol <1 mg/ml Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): 1. Wang J,et al. Int J Oncol. 2012 Sep;41(3):1101-9.2. Grozinger CM, et al. J Biol Chem. 2001 Oct 19;276(42):38837-43. Scientific Category: Deacetylase Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.